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The side effects will vary based on the substance - take a look at some examples
Prescription painkillers are amongst the most commonly abused drugs, and they pose some of the most potentially life-threatening symptoms of withdrawal. Symptoms of withdrawal often include severe agitation, anxiety, panic attacks, severe abdominal cramping, diarrhea, vomiting, muscle and bone pain, insomnia, and suicidal ideation linked to severe depression. Those who have abused prescription painkillers for any extent of time will need to undergo medical detox, and they will need to be monitored by a medical professional during the length of the withdrawal process.